One of the aims of the CiPA initiative is to integrate data from patch-clamp experiments on a range of important ion channels with in silico simulations of cardiac electrical activity. In the second component of CiPA screening, electrophysiology data generated using the expanded panel of six ion channels is incorporated into an in silico human ventricular action potential model. However, the acquisition of advanced software suites and massive computing capabilities are available to anyone with resources they are willing to invest. What makes the real difference is experience. Here at Creative Bioarray, we are ready to support our customers in silico modeling. With our simulations we can help to make sense of your data.

In silico models of cardiac electrical activity have become very sophisticated in recent years, and allow a better understanding of the complex non-linear interactions between the different ionic currents and ion concentrations within the cell. Readout from the model predicts changes in the action potential duration, a surrogate marker for QT prolongation, and generation of early after depolarizations (EADs) – with appearance of EADs being highly indicative of proarrhymic liability.