Over the past 30 years, many genetically engineered mouse lines have been generated to model human genetic diseases, including neuropsychiatric disorders. Mice exhibit about 90% gene homology with humans, and the protein-coding regions of the mouse and human genomes are on average 85% identical, supporting its high usefulness for studying molecular and behavioral changes involved in the pathogenesis of neurological diseases. Since behavior represents the final output of the central nervous system and is used to assess the effects of new drugs or genetic modifications, functional genetic analysis of mice modeled for neuropsychiatric disorders relies on efficient and in-depth characterization of behavioral profiles.

Source from: Behavioral Tests