Interspecies differences in ion channel composition and signal cascades can hinder the predictivity of the cardio-toxicity test by using non-human experimental models. However, traditional 2D cell culture models cannot recapitulate the human in vivo structure and organization of the myocardium and are lack of the crucial process of cardiomyocyte differentiation. What's more, conventional static 2D culture of adult myocytes fails to preserve the adult phenotype.

To overcome the weaknesses and limitations of current cell-based and animal-based testing, 3D models with the appropriate biophysical tissue architecture are generated for cardio-toxicity test in order to provide highly predictive and detailed information for the human in vivo study. Creative Bioarray offers the opportunity for highly predictable pre-clinical cardio-toxicity testing to help our customers to reduce both the cost and duration of bringing a new drug candidate to market.